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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 12
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Original Articles

p-TOLUENESULFONIC ACID-CATALYZED EFFICIENT SYNTHESIS OF DIHYDROPYRIMIDINES: IMPROVED HIGH YIELDING PROTOCOL FOR THE BIGINELLI REACTION

Tongshou Jin College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P.R. ChinaCorrespondence[email protected]
,
Suling Zhang College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P.R. China
&
Tongshuang Li College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P.R. China
Pages 1847-1851 | Received 20 Jun 2001, Published online: 17 Oct 2011
 
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ABSTRACT

Dihydropyrimidines are prepared by a one-pot cyclocondensation of aldehydes, β-ketoesters and urea with p-toluenesulfonic acid-catalyzed condensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction conditions.

ACKNOWLEDGMENTS

The work was supported by the NSFC (29872011 and 29572039), Educational Ministry of China and Educational Department of Hebei Province (99014), Science and Technology Commission of Hebei Province.

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