ABSTRACT
An efficient one step procedure for the preparation of (4.3.0) bicyclic N-methylpyrrolidine thymidine derivatives 4, using cycloaddition reaction of the highly reactive non-stabilized azomethine ylide [Y] with 3′,5′-Bis-O-silylthymidines 3.
ACKNOWLEDGMENTS
The authors are indebted to Consejo Nacional de Ciencia y Tecnología (CONACyT) for partial financial support (Project No 33366-E). Messrs, A. Acosta and L. Velasco for their technical assistance.