A NOVEL AND EFFICIENT SYNTHESIS OF 4-PHENYL-2-CHLOROPYRIMIDINES FROM ACETOPHENONE CYANOIMINES

ABSTRACT

A versatile and efficient 2 step synthesis of 4-phenyl-2-chloropyrimidines is described. The reaction proceeds by treatment of acetophenone cyanoimines under Vilsmeier–Haack conditions to give the target compounds in moderate yields.

Keywords:

• Vilsmeier
• Acetophenone
• Pyrimidine

ACKNOWLEDGMENTS

The authors would like to thank Drs. Brian Buckwalter and William Wood for their assistance and discussions in the preparation of this manuscript, Mr. Ron Lopata for mass spectral analysis and interpretation and Ms. Terri Verderese for typing the manuscript.