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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 20
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Original Articles

NEW 6-ETHOXYQUINOLINES AS SIMPLE OPTOQUINE ANALOGUES

Raymond C. F. Jones Department of Chemistry, Loughborough University, Loughborough, Leics, LE11 3TU, UKCorrespondence[email protected]
,
Russell J. Collighan Department of Chemistry, Nottingham University, Nottingham, NG7 2RD, UK
,
Joanna Crane Department of Chemistry, Nottingham University, Nottingham, NG7 2RD, UK
,
Nikolas J. Hodges Department of Chemistry, Nottingham University, Nottingham, NG7 2RD, UK
,
Matthew S. Ling Department of Chemistry, Nottingham University, Nottingham, NG7 2RD, UK
&
Joanne Stroud Department of Chemistry, Nottingham University, Nottingham, NG7 2RD, UK
Pages 3185-3191 | Received 29 Oct 2001, Published online: 16 Aug 2006
 
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ABSTRACT

Reaction of 6-ethoxylepidine (6-ethoxy-4-methylquinoline) with strong base and electrophiles leads to new derivatives, as possible optoquine analogues.

ACKNOWLEDGMENTS

We thank Dr. A. R. Mellersh (Derby City Hospital) for biological data and financial assistance, and Parke-Davis Neuroscience Research Unit for partial financial support (M. S. L.).

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