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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 1
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Original Articles

Mild and Efficient Synthesis of Phthalazine-1,4-diones Using PTSA in the Solid State

, , &
Pages 127-131 | Received 29 Oct 2001, Published online: 20 Aug 2006
 

Abstract

A rapid and efficient method for the synthesis of 1,8-naphthyridine-3-carbonyl phthalazine-1,4-diones by the condensation of 1,8-naphthyridine-3-carboxylic acid hydrazides with phthalic anhydride using p-toluenesulphonic acid (PTSA) as a catalyst under solid state conditions has been described. The reaction proceeds efficiently at room temperature in excellent yields and in a state of high purity.

Acknowledgments

We are grateful to the Directors, IICT, Hyderabad, and CDRI, Lucknow, for providing spectral data. DSC thanks UGC, New Delhi for research fellowship.

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