Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 3
Submit an article Journal homepage
166
Views
8
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis of Benzomacrolactam by 12-endo Selective Aryl Radical Cyclization of N-(4-Allyloxybutyl)-2-iodobenzamide

André Augusto Gomes Faraco Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, Brazil
,
Maria Auxiliadôra F. Prado Departamento do Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Olegário Maciel 2360, Belo Horizonte, BrazilCorrespondence[email protected]
,
Ricardo J. Alves Departamento do Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Olegário Maciel 2360, Belo Horizonte, Brazil
,
José D. Souza Filho Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, Brazil
,
Rosemeire Brondi Alves Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, Brazil
&
Renata F. Prado Faraco Departamento do Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Olegário Maciel 2360, Belo Horizonte, Brazil
Pages 463-474 | Received 22 Feb 2002, Published online: 17 Aug 2006
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Regioselective 12-endo aryl radical cyclization of N-(4-allyloxybutyl)-2-iodobenzamide (7) with tri-n-butyltin hydride provided benzomacrolactam 15. The structure of 15 is supported by 1H and 13C NMR spectroscopy and by DEPT, COSY, COSYLR and HMQC experiments.

Acknowledgments

A. G. Faraco, R. F. P. Faraco, M. A. F. Prado, and R. B. Alves thank Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for fellowships. The authors thank Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) for financial support.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 422.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.