Stereoselective Synthesis of α-Bromo-α,β-unsaturated Ketones via Wittig Reaction

Abstract

The synthesis of α-bromo benzoylmethylene triphenylphosphorane 2 is firstly reported and α-bromo ylide 2 has sufficient activity to undergo Wittig reaction, affording a novel method for the stereoselective synthesis of α-bromo-α,β-unsaturated ketones 5.

Acknowledgment

We thank the National Natural Science Foundation of China for its financial support of the project 29972036.