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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 7
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Original Articles

Synthesis of Guanidine Derivatives and Molecular Recognition

, , , &
Pages 1073-1079 | Received 19 Nov 2001, Published online: 21 Aug 2006
 

Abstract

Five Guanidine Derivatives bearing acyl group were synthesized by the reaction of acyl chloride with 1,1,3,3-tetramethylguanidine. Their structures were confirmed by IR, 1H-NMR, EI-MS, HRMS and elementary analysis. One of them (4a) was also characterized by X-ray. Preliminary results of interaction with phosphate-containing biomolecules and adipate showed that all of them exhibited the abilities of molecular recognition.

Acknowledgment

This work was funded by National Natural Science Foundation of China (No. 29933050).

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