Abstract
A convenient synthesis of 1,4,7-Triazacyclononane (tacn) derivatives substituted with a single pendant donor group is described. Mono-substituted tacns with a hydroxylalkyl, an aminoalkyl, or a benzyl group are synthesized via efficient cyclization of inexpensive starting materials followed by detosylation.
Acknowledgment
We thank the structural Mass Spectra Group (Dr. L. Pannell, NIDDK, Bethesda, MD) for obtaining the mass spectra of compounds.