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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 7
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Original Articles

A Short and Efficient Synthesis of Mono-substituted 1,4,7-Triazacyclononanes

Hyun-soon Chong Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
&
Martin W. Brechbiel Chemistry Section, Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland, USACorrespondence[email protected]
Pages 1147-1154 | Received 15 May 2002, Published online: 21 Aug 2006
 
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Abstract

A convenient synthesis of 1,4,7-Triazacyclononane (tacn) derivatives substituted with a single pendant donor group is described. Mono-substituted tacns with a hydroxylalkyl, an aminoalkyl, or a benzyl group are synthesized via efficient cyclization of inexpensive starting materials followed by detosylation.

Acknowledgment

We thank the structural Mass Spectra Group (Dr. L. Pannell, NIDDK, Bethesda, MD) for obtaining the mass spectra of compounds.

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