An Efficient Strategy for the Synthesis of Chiral Liquid Crystals Using Evans' Methodology

Abstract

The synthesis of liquid crystal compound 2 was achieved using Evans' methodology. The strategy was based on three key synthetic reactions: alkylation of chiral amide enolates, Mitsunobu and, finally, esterification. The final compound presents a stable smectic A phase.

Acknowledgment

The authors acknowledge PADCT-CNPq, FAPERGS for financial support. Mirele S. Fernandes is a undergraduate student and acknowledges PADCT-III and PIBIC-UFRGS for a fellowship.