Abstract
The title compounds were designed and synthesized as candidate cytotoxic agents. They were synthesized by reacting 3,5-bisphenylmethylene-piperidin-4-one with the appropriate 3-arylcarbamoyl-acrylic acids. These reactions follow an unusual mechanism and deviate from the previously reported reactions on similar substrates.
Acknowledgments
We thank Purdue Neuroscience Company, USA for financial support.