Abstract
We found an efficient methodology for the Baylis-Hillman reaction of p-nitrobenzaldehyde (1), naphtaldehyde (4a), and pyperonal (4b) with methyl acrylate by using 4-dimethylaminopyridine (DMAP) as a catalyst, without solvent, additives, or any sophisticated equipment. A very important temperature effect was observed.
Acknowledgments
National Research Council of Brazil (CNPq), José Bonifácio University Foundation (FUJB-Brazil), and Research Foundation of the Rio de Janeiro (FAPERJ) for a fellowship.