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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 12
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Original Articles

Aqueous Trichloroacetic Acid: Another Useful Reagent for Highly Selective 5′-Desilylation of Multisilylated Nucleosides

Xue-Feng Zhu Center for Biological NMR, Department of Chemistry, Texas A&M University, College Station, Texas, USA
,
Howard J. Williams Center for Biological NMR, Department of Chemistry, Texas A&M University, College Station, Texas, USA
&
A. Ian Scott Center for Biological NMR, Department of Chemistry, Texas A&M University, College Station, Texas, USACorrespondence[email protected]
Pages 2011-2016 | Received 16 Sep 2002, Published online: 17 Aug 2006
 
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Abstract

Highly selective 5′-desilylation of multisilylated nucleosides can be achieved in excellent yield by treatment with 4.2 M aqueous trichloroacetic acid:THF (1:4) at 0°C.

Acknowledgments

This work was supported by grants from the Texas Advanced Technology Research Program and the Robert A. Welch Foundation. X. F. Z. thanks members of the Scott group, especially Dr. Clotilde Pichon-Santander, for offering him invaluable help during his post-doctoral appointment at Texas A&M University.

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