Microwave-Assisted Coupling of Carboxylic Acids to a Polymer Bound Hydrazine Linker

Abstract

A set of carboxylic acids, all being potential scaffolds for combinatorial chemistry or peptide synthesis, were coupled to a polymer bound aryl hydrazine linker using microwave irradiation in good yields. Improved yields and reduced reaction times were achieved by using microwave-assisted heating compared to conventional heating.

Acknowledgments

This work was financially supported by Amersham Biosciences and the Swedish Research Council.