Abstract
Kinetic resolutions by lipase-catalyzed transesterification with 3-iodocyclohex-2-en-1-ol or 3-iodocyclohex-2-en-1-yl acetate followed by inversion of the chirality of the optically active alcohol without separation from the acetate have allowed the preparation of (R)- and (S)-3-iodocyclohex-2-en-1-yl acetate with more than 70% yield and more than 85% ee.
Acknowledgment
We are grateful to Novo Nordisk A/S (Denmark) for a gift of Novozym®.