Abstract
5-Isopropylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (the condensation product of Meldrum's acid and acetone) reacts smoothly with tert-butyl isocyanide in the presence of alcohols to produce alkyl 1-tert-butyl-4,4-dimethyl-2,5-dioxo-pyrrolidine-3-carboxylate and dialkyl 2-(1-tert-butylcarbamoyl-l-methyl-ethyl)-malonates in good overall yields.
Acknowledgments
This research was supported by the National Research Council of the Islamic Republic of Iran (NRCI) as a National Research project under the grant number 989.