Abstract
Investigation of the key step of 3-aminophenothiazine (5) synthesis, that is thiation of N-(4-phenylaminophenyl)-phthalimid (3) was carried out. The best results were achieved using microwave irradiation, when 55% of the pure thiation product 3-phalimidophenothiazine (4) were isolated in 10–20 min reaction time.
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Acknowledgments
Our thanks are due to Dr. Eva Solčaniová from Comenius University, Faculty of Natural Sciences, Institute of Chemistry for NMR measurements, and to the Slovak Grant Agency VEGA for the financial support (Grant No. 1/7348/20).