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Abstract
An efficient PEG-supported liquid-phase parallel synthesis of phenyloxyacetyl thioureas is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of primary arylamine gave PEG-bound phenyloxyacetyl thioureas, which was easily cleaved to give the resulting library in good to high yield and high purity.
Acknowledgment
The authors thank the Scientific and Technological Innovation Engineering of Northwest Normal University (NWNU-KJCXGC-02-08), Natural Science Foundation of Gansu Province (ZS021-A25-006-Z), Environmental Protection Foundation of Gansu Province (GH2002-16) for the financial support of this work.