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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 24
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Original Articles

One Pot Synthesis of Methyl Aminoacetylcyanoacetates

Stylianos Hamilakis The Laboratory of Organic Chemistry, The School of Chemical Engineering, The National Technical University of Athens, Athens, Greece
&
Assistant Professor Athanase Tsolomitis The Laboratory of Organic Chemistry, The School of Chemical Engineering, The National Technical University of Athens, Athens, GreeceCorrespondence[email protected]
Pages 4313-4319 | Received 19 Jun 2003, Published online: 21 Aug 2006
 
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Abstract

The C-acylation reactions of the methyl cyanoacetate with N-protected glycines by simultaneous activation of the amino acid carbonyl group and the methyl cyanoacetate methylene group using carbonyl diimidazole (CDI) have been here performed. The corresponding aminoacetylcyanoacetates were isolated (devoided of any impurities) as enols 4 in high yields, with a simple experimental, one pot, procedure.

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