Synthesis of 1,3-Oxazolidines and 1,3-Dioxolanes by Reaction of (2R, 3R)-3-Methylamino-3-phenyl-1,2-propanediol with Electrophiles

Abstract

The chemoselective reaction of (2R, 3R)-3-methylamino-3-phenyl-1,2-propanediol 1 with dimethoxypropane and dichloromethane under different conditions are reported as useful preparative procedures, for the synthesis 1,3-oxazolidines and 1,3-dioxolanes.

Keywords:

• Oxazolidines
• Dioxolanes
• Chemoselectivity

Acknowledgments

We are indebted to Dirección General de Investigación Científico y Técnica, for project PB98-1451.