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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 6
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Original Articles

Efficient DMTMM Promoted Nucleoside Loading of CPG Solid Support for Oligonucleotide Synthesis

, &
Pages 1071-1077 | Received 22 Sep 2003, Published online: 21 Aug 2006
 

Abstract

A simple and efficient process for the attachment of protected 2′‐deoxynucleosides to the solid support controlled pore glass (CPG) via succinyl linkage using the mild, non‐carbodiimide dehydrating agent 4‐(4,6‐dimethoxy‐1,3,5‐triazin‐2‐yl)‐4‐methylmorpholinium chloride (DMTMM) has been developed. The protocol is cost effective, does not require anhydrous conditions and is easy to implement.

Acknowledgement

One of the authors MCU is thankful to Isis Pharmaceuticals for the financial assistance and gift of various chemicals and reagents. We also thank Dr. D. L. Cole for his continued support of this project.

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