Abstract
Precipitation of products by using dichloromethane as solvent permits an efficient aldol‐type reaction between 1,4‐diacetyl‐2,5‐piperazinedione and aromatic aldehydes catalyzed by K t BuO/ t BuOH independently of the electrophilic character of the aryl ring. A simple method to obtain 3‐methyl‐2,4,5‐trimethoxybenzaldehyde is also reported.
Acknowledgment
Financial support of this research from CICYT (SAF2000‐0130/99) and a FPI fellowsip (J. F. González) is gratefully acknowledged.