Abstract
Various (aliphatic, aromatic, and heterocyclic aromatic) types of aldoximes were converted into the corresponding nitriles in good to excellent yields using 2‐chloro‐1‐methylpyridinium iodide (CMPI) as a dehydrating agent under mild conditions.
Acknowledgments
This work was financially supported through the Academic Research Fund of Woosuk University.
Notes
aWhen primary amide such as m‐nitrobenzamide or 5‐phenylvalerylamide was reacted with CMPI (1.05 equiv) and Et3N (2.10 equiv) in CH2Cl2 at rt for 4 hr under Ar, no reaction occurred.