Abstract
The conformationally locked s‐trans enone functionality present in the (E)‐2‐arylidene‐1‐cyclohexanones undergoes regioselective 1,3‐dipolar cycloaddition reaction with azomethine ylides generated by the decarboxylative route from tetrahydroisoquinoline‐3‐carboxylic acid and isatin. The regio and stereochemistry of the title compound was established by spectroscopic techniques.