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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 10
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Original Articles

A Facile Synthesis of Dispiro[oxindole‐cyclohexanone] Pyrroloisoquinoline by Formal 1,3‐Dipolar Cycloaddition Strategy

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Pages 1825-1830 | Received 01 Jan 2004, Published online: 20 Aug 2006
 

Abstract

The conformationally locked s‐trans enone functionality present in the (E)‐2‐arylidene‐1‐cyclohexanones undergoes regioselective 1,3‐dipolar cycloaddition reaction with azomethine ylides generated by the decarboxylative route from tetrahydroisoquinoline‐3‐carboxylic acid and isatin. The regio and stereochemistry of the title compound was established by spectroscopic techniques.

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