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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 12
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Original Articles

Mild and Efficient Synthesis of 1,8‐Naphthalide and 1,8‐Naphthalenedimethanol

, , , , &
Pages 2269-2275 | Received 15 Dec 2003, Published online: 17 Aug 2006
 

Abstract

Mild and efficient procedures have been developed for synthesis of 1,8‐naphthalide and 1,8‐naphthalenedimethanol. In an ice‐water bath, 1,8‐naphthalide was prepared from 1,8‐naphthlic anhydride using LiAlH4 as reducing agent. 1,8‐Naphthalenedimethanol was obtained with good yield from reduction of 1,8‐naphthalic anhydride by LiAlH4 and Lewis acids at room temperature. The effects of various factors on the reduction of 1,8‐naphthalic anhydride with LiAlH4 were investigated.

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