Direct Synthesis of N‐Acylalkylenediamines from Carboxylic Acids Under Mild Conditions

Abstract

Monoacylated piperazine derivatives were prepared directly from carboxylic acids and piperazine using triphenylphosphine (TPP) and N‐bromosuccinimide (NBS) in dichloromethane. Inexpensive and readily available reagents, excellent yields, short reaction times and mild reaction conditions are important features of this method.

Keywords:

• Monoacylated derivatives of diamines
• Triphenylphosphine
• N‐bromosuccinimide
• Carboxylic acids