Carbohydrate Derivative from Baylis–Hillman Adduct. An Easy and Short Synthesis of 2‐Deoxy‐2‐C‐methylene‐D‐erythro‐pentono‐1,4‐lactone

Abstract

A simple and straightforward approach for the synthesis of an α‐methylene‐δ‐butyrolactone from a Baylis–Hillman adduct obtained from a chiral α‐hydroxy aldehyde, is described.

Keywords:

• Baylis–Hillman reaction
• Butyrolactone
• α‐Hydroxy aldehyde
• Chirality

Acknowledgments

We thank FAPESP for a fellowship to R.S.P. (03/05410‐0) and for financial support (02/00461‐3). We also thank the Brazilian National Research Council (CNPq‐301369/1987‐9) for a research fellowship to F.C. The authors are grateful to Prof. Carol H. Collins for English revision of this manuscript.