Trimethylsilyl Chloride: A Facile and Efficient Reagent for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones

Abstract

Trimethylsilyl chloride (TMSCl) was used as a Lewis acid to efficiently perform one‐pot, three‐components, Biginelli condensation reactions of aldehydes, 1,3‐dicarbonyl compounds, and urea or thiourea. This resulted in simple one‐pot synthesis of the corresponding 3,4‐dihydropyrimidin‐ 2(1H)‐ones at room temperature with excellent yield.

Keywords:

• Biginelli reaction
• Trimethylsilyl chloride
• Lewis acid
• 3,4‐Dihydropyrimidin‐2(1H)‐ones

Acknowledgments

This research was funded by NSFC of China (20375036) and NSF of Zhejiang Province (Rc0042)