A Facile Synthesis of 4‐(O,O‐Dialkylphosphoryl)‐1,3‐oxazole by Rhodium‐Catalyzed Heterocycloaddition

Abstract

A series of 4‐phosphoryl substituted 1,3‐oxazole are prepared conveniently by reaction of diethyl 1‐diazo‐2‐oxo‐alkylphosphonates and aromatic nitriles in the presence of a catalytic amount of rhodium(II) acetate.

^#Studies on Organophosphorus Compounds, Part 131. For Part 130, see C. Xu and C. Yuan, Tetrahedron 2004, 60, 3883–389.

Keywords:

• Heterocycloaddition
• Phosphoryl oxazole
• Rhodium‐catalyzed

Acknowledgment

The project was supported by the National Natural Science Foundation of China (Grant No. 20272075 and 20372076).

Notes

^#Studies on Organophosphorus Compounds, Part 131. For Part 130, see C. Xu and C. Yuan, Tetrahedron 2004, 60, 3883–389.