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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 18
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Original Articles

Improved Synthesis of 7‐(Alkyl/aralkyl)guanines

A. Vidal INSERM UMR 484, Rue Montalembert, BP 184, 63005, Clermont‐Ferrand Cedex, FranceCorrespondence[email protected]
,
I. Giraud INSERM UMR 484, Rue Montalembert, BP 184, 63005, Clermont‐Ferrand Cedex, France
&
J.‐C. Madelmont INSERM UMR 484, Rue Montalembert, BP 184, 63005, Clermont‐Ferrand Cedex, France
Pages 3359-3365 | Received 30 Mar 2004, Published online: 10 Jan 2011
 
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Abstract

A rapid and convenient preparation of 7‐(alkyl/aralkyl)guanines from guanosine is described. Using this method, a series of 7‐substituted guanines (compounds 2a–k) was synthesized in good yields (51%–97%).

Notes

aThe NH proton in 2a, 2b, 2g, 2h, 2i, and 2k were not distinctly observed in the 1H NMR spectra presumably due to rapid exchange with traces of water.

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