A Convenient Synthesis of 1‐Tosyl‐3, 4‐Dimethyl Imidazolium Salt and N,N,N′‐Trisubstituted Ethylendiamine Derivatives

Abstract

1‐Tosyl‐3,4‐dimethyl imidazolium iodide 3 was prepared by convenient cyclization, sulfonylation, and methylation from 4‐methyl‐2‐imidazoline, which was obtained by the reaction of ethyl formate with 1,2‐diaminopropane. Monofunctional carbon nucleophiles reacted with 3 to yield a series of N,N,N′‐trisubstituted ethylendiamine derivatives.

Keywords:

• Synthesis
• THF coenzyme model
• N,N,N′‐trisubstituted ethylendiamine
• 1‐tosyl‐3,4‐diamethyl‐imidazolium

Acknowledgments

This work was supported by the National Natural Science Foundation of China (20272034) and the Natural Science Foundation of Shanxi Province, China (20041007 and 20041006).

Supporting information available: X‐ray data for model compound 3 (CIF).