Efficient and Selective Formation of Mixed Acetals by Nafion‐H SAC‐13 Silica Nanocomposite Solid Acid Catalyst

Abstract

Various types of hydroxy compounds can readily be converted to the corresponding mixed acetals with dialkoxymethanes in the presence of SAC‐13 solid superacid. The transformation is almost instantaneous, product acetals are isolated in good to excellent yields, and the catalyst can be reused with minor loss of activity. Comparative studies were also carried out with p‐toluenesulfonic acid and BF₃ · OEt₂.

Keywords:

• Dialkoxymethanes
• Hydroxy compounds
• Mixed acetals
• Nafion SAC‐13
• Protecting groups
• Superacid

Acknowledgment

This work was sponsored by the National Research Foundation of Hungary (Grant OTKA T042603).