Abstract
An efficient synthesis of 3,4‐dihydropyrimidinones (DHPMs) using bismuth subnitrate as the catalyst for the first time from an aldehyde, β‐ketoester, and urea in acetonitrile is described. This new method consistently has the advantage of excellent yields (88–96%) and short reaction times (1.5–4 h) than do classical Biginelli reaction conditions.
Acknowledgment
The authors are thankful to AICTE, New Delhi, for financial assistance and to the director, IICT, Hyderabad for 1H‐NMR and mass spectral analysis.