Abstract
A series of pyrido[2,3‐d]pyrimidine derivatives was synthesized by the reaction of arylaldehyde, malononitrile, and 4‐amino‐2,6‐dihydroxylpyrimidine in ethyl alcohol at 80°C catalyzed by KF‐Al2O3. Compared with other synthetic methods, this new method has the advantage of easier workup, milder reaction conditions, and good yields.
Acknowledgment
We are grateful to the Foundation of the “Surpassing Project” of Jiangsu Province and Natural Science Foundation of the Education Committee of Jiangsu Province for financial support.