Abstract
Reaction of 5‐amino‐3‐substituted pyrazoles (1a–c) and 5‐amino‐1,3‐disubstituted pyrazoles (1d–i) with fluorinated‐β‐diketones (2) results in the formation of the single isomer of pyrazolo[3,4‐b]pyridines (4a–h). A one‐pot procedure for the synthesis of title compounds starting from α‐cyanoacetophenones along with a possible mechanistic pathway for the formation of the title compounds is described.
Acknowledgments
We are thankful to the RSIC, Punjab University Chandigarh, India, for 19F NMR and 1H NMR spectra, elemental analysis, and IR spectra. Thanks are due to Ranbaxy Laboratories, New Delhi, India, for the financial assistance.