Scandium Triflate as an Efficient and Recyclable Catalyst for the Deprotection of Tert‐Butyl Aryl Sulfonamides

Abstract

A mild and efficient method for deprotection of tert‐butyl sulfonamide groups utilizing Sc(OTf)₃ as deprotecting reagent has been developed. A variety of tert‐butyl aryl sulfonamides used under these conditions gave the corresponding primary sulfonamides in high yields. The Lewis acid catalyst could be fully recovered and reused with maintained activity after the reactions.

Keywords:

• Scandium triflate
• sulfonamide
• deprotection
• catalyst

Acknowledgment

We gratefully acknowledge support from the Swedish Foundation for Strategic Research (SSF).