Abstract
Heptadienes containing nucleic bases are attractive building blocks for the synthesis of carbocyclic oligonucleotide analogs. Herein, we report an alternative synthetic route to 4‐[(1H,3H)‐pyrimidine‐2,4‐dion‐1‐yl]‐1,6‐heptadiene and 4‐[(1H,3H)‐5‐methylpyrimidine‐2,4‐dion‐1‐yl]‐1,6‐heptadiene via building the pyrimidine ring utilizing 4‐isocyanato‐1,6‐heptadiene intermediate.
Acknowledgments
The authors are grateful to the Lebanese National Council for Scientific Research (LNCSR) for partial financial support of this research project.