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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 13
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Original Articles

Organic Reactions in Ionic Liquids: Ionic Liquid‐Accelerated One‐Pot Synthesis of 2‐Arylimidazo[1,2‐a]pyrimidines

Yuan‐Yuan Xie College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaCorrespondence[email protected]
Pages 1741-1746 | Received 14 Feb 2005, Published online: 15 Aug 2006
 
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Abstract

The room‐temperature ionic liquid n‐butylpyridinium tetrafluoroborate (BPyBF4) is used as a recyclable alternative to classical molecular solvents in the one‐pot synthesis of 2‐arylimidazo[1,2‐a]pyrimidines by reaction with ketones, [hydroxy(tosyloxy)iodo]benzene, and 2‐aminopyrimidine. Significant rate enhancements and improved yields have been observed.

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