Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by New Chiral Oxazolidine Ligand

Abstract

The chiral oxazolidine ligand can catalyze the enantioselective addition of diethylzinc to aromatic aldehydes at room temperature with high enantioselectivity (98–99% ee). The conditions for this catalytic process are both mild and simple as compared with the same kind catalyst.

Keywords:

• Oxazolidine
• addition
• diethylzinc
• aldehydes
• enantioselectivity

Acknowledgments

We are grateful to the National Natural Science Foundation of China (Nos. 20372028, 20472026), the Ministry of Science and Technology of China, the Teaching and Research Award Program for Outstanding Young Teachers, and the Specialized Research Fund for the Doctoral Program in Higher Education Institutions of the Ministry of Education of China.