Three‐Component, One‐Pot Synthesis of Pyrido[2,3‐d]pyrimidine Derivatives Catalyzed by KF‐alumina

Abstract

A series of pyrido[2,3‐d]pyrimidine derivatives were synthesized by the three‐component reaction of arylaldehyde, cyanoacetate, and 4‐amino‐2,6‐dihydroxylpyrimidine in ethyl alcohol at 80°C catalyzed by KF‐Al₂O₃. It was interesting that further aromatization took place automatically. Compared with other synthetic methods, this new method has the advantage of easier workup, milder reaction conditions, and good yields.

Keywords:

• Aromatization
• KF‐Al₂O₃
• pyrido[2,3‐d]pyrimidine
• synthesis

Acknowledgments

We are grateful to the Foundation of the “Surpassing Project” of Jiangsu Province and Natural Science Foundation (No. 04KJB150139) of the Education Committee of Jiangsu Province for financial support.