SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF N-ISONICOTINOYL- N′-THIOBENZOYLHYDRAZINE COMPLEXES OF Co(II), Ni(II), Cu(II), AND Zn(II)

ABSTRACT

A new ligand, N-isonicotinoyl-N′-thiobenzoylhydrazine (HINTB), has been prepared by the reaction of isonicotinic acid hydrazide and carboxym ethyl dithiobenzoate. The addition complexes [M(HINTB)₂Cl₂] [M=Co(II), Ni(II), Zn(II)], [Cu(HINTB)Cl₂], M(HINTB)₂(CH₃COO)₂ [M=Co(II), Ni(II)] and deprotonated complexes [Cu(INTB)(CH₃COO)] and [Zn(INTB)₂] have been prepared and characterized by elemental analyses, magnetic susceptibility, electronic, NMR and IR spectral data. The room temperature ESR spectra of [Cu(HINTB)Cl₂] and [Cu(INTB)(CH₃COO)] are characteristic of monomeric and dimeric species, respectively. The ligand and the complexes have been screened for activity against a number of fungi and bacteria.

Acknowlegments

The authors thank Dr. V. B. Chauhan, Plant Pathology Division, Institute of Agricultural Sciences, B.H.U. and Dr. Gopal Nath, Microbiology Division, Institute of Medical Sciences, B.H.U. for antimicrobial screening. Thanks are also due to the Head, Regional Sophisticated Instrumentation Centre, Central Drug Research Institute, Lucknow for microanalyses.