ABSTRACT
In an effort to develop new organotin materials for investigation and biocidal evaluation, a series of compounds with the general formula R4−nSnLn (where R=CH3, n-C4H9, C6H5, C6H5CH2 and L=2-(N-maleoyl)-3-phenylpropanoic acid anion) have been synthesized, and characterized by elemental analyses, IR, multinuclear (1H, 13C and 119Sn) NMR and mass spectrometry. The biological activity of these compounds against various bacteria and fungi has been investigated. All of the compounds were found to be active against the tested fungi with a few exceptions. These compounds also showed significant antibacterial activity. LD50 data show that the investigated compounds also have significant toxicity.
ACKNOWLEDGMENTS
SA is thankful to the Quaid-i-Azam University, Islamabad, Pakistan, for financial support of this work and the Alexander von Humboldt Foundation for award of a Georg Forster Research Fellowship. We are indebted to Prof. B. Wrackmeyer, University of Bayreuth, Germany for providing multinuclear NMR and mass spectral facilities.