Binary and Mixed Ligand Complexes of Nifuroxime, Spectral, and Thermal Studies

Abstract

Complexes of nifuroxime (anti‐5‐nitro‐2‐furfuraldoxime, 5N‐FDH) with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), La(III) and UO₂(VI) have been prepared and characterized by elemental analyses, conductivity measurements, spectral and thermal studies. Also, some mixed nifuroximato‐phenylalaninato,‐tyrosinato or ‐methioninatonickel(II) complexes have been prepared and characterized by the previous methods. The complexes have the general formulae: [M(5N‐FD)₂·mH₂O]_n; [La(5N‐FD)(OOCCH₃)₂(H₂O)₂]₂; [UO₂(5N‐FD)₂]·2H₂O and [Ni(5N‐FD)(L)]·H₂O where M = Mn(II) Co(II), Ni(II), Cu(II), Zn(II) or Cd(II); m = 0 for M = Mn(II), m = 1 for M = Co(II), Ni(II) or Cd(II) and m = 2 for M = Cu(II) or Zn(II); L = phenylalaninate, tyrosinate or methioninate. All complexes were isolated at pH 6 using NH₄OH solution. Nifuroxime acts as a uninegative ligand in all complexes with various modes of coordination. Thermogravimetric studies show a rapid decomposition stage for all the complexes accompanied by other slow stages; the final product of all complexes is the metal oxide.

Keywords:

• Nifuroxime
• Metal oximate
• Amino acids