Synthesis, Characterization and Antifungal Studies of Metal Complexes of Benzoyl‐ and Salicylylhydrazones of ω‐Bromoacetoacetanilide

Abstract

Ten new transition metal complexes of benzoylhydrazone (L¹H₂) and salicylylhydrazone (L²H₃) of ω‐bromoacetoacetanilide have been synthesized. These complexes were characterized mainly by elemental analyses, molar conductance and magnetic susceptibility measurements along with electronic, infrared, and ¹H NMR spectral studies. Antifungal tests of the ligands and their Mn(II), Co(II), Ni(II), and Cu(II) complexes were also carried out. The antifungal activities of the complexes were greater than those of the ligands.

Keywords:

• Antifungal studies
• characterization
• metal complexes
• omega–bromoacetoacetanilide benzoyl– and salicylylhydrazones
• synthesis

Acknowledgments

The authors thank Prof. Dr. M.P Kannan, former Head of the Department of Chemistry, University of Calicut and the Heads, Regional Sophisticated Instrumentation Centre, Central Drug Research Institute, Lucknow; Punjab University, Chandigarh and Regional Sophisticated Instrumentation Centre, Indian Institute of Technology, Mumbai for providing laboratory facilities. Thanks are also due to the University Grants Commission, New Delhi for financial assistance.