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Abstract
A sensitive stability indicating method for the determination of nizatidine in the presence of its degradation products is developed. The proposed method is based on measuring the peak heights of the first derivative spectra at 680 nm of the blue reaction product developed from the reaction of nizatidine with 3-methyl-2-benzothiazolinone hydrazone (MBTH) in the presence of ferric chloride. The concentration of MBTH, and type of oxidising agent and its concentration were studied over time. The suggested procedure is simple, rapid and readily adaptable for the determination of pure nizatidine in bulk powder. Laboratory prepared mixtures and pharmaceutical preparations in the range of 1.6–8 μg · ml−1 of reaction mixture can be analysed. The results obtained were compared statistically with those obtained by applying the official USP XXIII (1995) method. Furthermore, the validity of the results was assessed by applying the standard addition technique.