ANALYSIS OF MEBENDAZOLE POLYMORPHS BY FOURIER TRANSFORM INFRARED SPECTROMETRY USING CHEMOMETRIC METHODS

Abstract

A Fourier transform infrared (FT-IR) spectrometric method diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) was developed for the rapid, direct measurement of mebendazole in drugs. Conventional KBr-spectra and DRIFTS-spectra were compared for best determination of active substance in drug formulations. Two chemometric approaches, partial least-squares (PLS2) and principal component regression (PCR+) methods were used in data procesing. The best results were obtained with the PLS2 method.

Keywords:

• Fourier transform infrared spectrometry
• Polymorphic analysis
• Mebendazole drug analysis
• Chemometric analysis

ACKNOWLEDGMENTS

One of the authors (AAB) wishes to thank to the Administration of O. F. SYSTEM AG for the financial support of the research programs. Also the author (HYA-E) wishes to thank the Administration of King Faisal Specialist Hospital & Research Centre for its support to the Bioanalytical and Drug Development Laboratory Research programs.