Enantioselective Separation of Several Piperidine-2,6-dione Drugs on Chirose C-1 Chiral Stationary Phase

Abstract

A newly developed Chirose C-1 chiral stationary phase, a highly chiral polymer, has been used for direct and isocratic enantiomeric separation of 12 piperidine-2,6-dione compounds under normal phase conditions. Baseline separation has been achieved for eight compounds, three compounds were partially separated, while one compound did not resolve.

Keywords:

• Piperidine-2,6-dione
• High-performance liquid chromatography
• Chiral separation
• Chiral polymer
• Chirose C-1 chiral stationary phase
• Normal phase mode

ACKNOWLEDGMENT

The authors thank the administration of the King Faisal Specialist Hospital and Research Center for their support to the Bioanalytical and Drug Development Research Program.