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Journal of Toxicology: Toxin Reviews Volume 22, 2003 - Issue 4
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Research Article

Novel Taxane Diterpenoids from Taiwanese Yew Trees

Ya‐Ching Shen Institute of Marine Resources, National Sun Yat‐sen University, 70 Lien‐Hai Rd., Kaohsiung, Taiwan, Republic of China
,
Yao‐To Chang Institute of Marine Resources, National Sun Yat‐sen University, 70 Lien‐Hai Rd., Kaohsiung, Taiwan, Republic of China
,
Shih‐Sheng Wang Institute of Marine Resources, National Sun Yat‐sen University, 70 Lien‐Hai Rd., Kaohsiung, Taiwan, Republic of China
,
Yu‐Ling Pan Institute of Marine Resources, National Sun Yat‐sen University, 70 Lien‐Hai Rd., Kaohsiung, Taiwan, Republic of China
,
Kuang‐Liang Lo Institute of Marine Resources, National Sun Yat‐sen University, 70 Lien‐Hai Rd., Kaohsiung, Taiwan, Republic of China
&
Yu‐Chi Lin Institute of Marine Resources, National Sun Yat‐sen University, 70 Lien‐Hai Rd., Kaohsiung, Taiwan, Republic of China
Pages 533-545 | Published online: 12 Nov 2003
 
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Abstract

Recent discovery of new and bioactive taxane diterpenoids from the roots, barks, seeds, leaves and the stems of Taxus mairei and T. sumatrana, Taiwanese yew trees are described. More than thirty new compounds including taxumatrols A and B (36, 37) have been isolated and their structures determined by spectroscopic analysis and chemical derivatization and correlation. Some of the isolated taxoids exhibited potent cytotoxicity against human tumor cells.

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