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Author's Correction

Cooperative Action of Multiple cis-Acting Elements Is Required for N-myc Expression in Branchial Arches: Specific Contribution of GATA3

Pages 5152-5153 | Published online: 20 Mar 2023
This article refers to:
Cooperative Action of Multiple cis-Acting Elements Is Required for N-myc Expression in Branchial Arches: Specific Contribution of GATA3

AUTHOR'S CORRECTION

Volume 30, no. 22, p. 5348–5363, 2010. While extending the results of our paper to characterize the repressor element located in the first N-myc intron, Laurent Beuret of our laboratory identified a mutation in the vector that was used to generate constructs 9 and 10 of Fig. 3, leading to the truncation of the β-galactosidase and loss of its enzymatic activity. Results obtained with construct 9 are retracted, since experiments with this construct were not repeated, whereas transgenic experiments with a corrected version of construct 10 were reperformed. The results obtained differ from the initial report, leading to a different interpretation that we would like to correct. The primary difference is that lacZ expression is observed in the branchial arches with the new construct 10. This result indicates that the branchial arch enhancer located in the second intron acts in the N-myc context as well as on a heterologous promoter. It also shows that the first intron does not act as a repressor or does not contain a negative element for the branchial arch enhancer as proposed in our initial report. We sincerely regret this error and any inconvenience that it may have caused our colleagues.

Page 5351, Fig. 3A, B, and C: Construct 9 and the results associated are withdrawn.

Page 5351, Fig. 3B: The results for the experiment with construct 10, modified according to the data obtained with the corrected version of construct 10, should appear as shown below.

Page 5351, Fig. 3C: The panel for construct 10 should appear as shown below, so that it is replaced with a representative specimen obtained with the corrected version.

Page 5361, Fig. 10: The schematic model of N-myc gene regulation should appear as shown below to take into account that the branchial arch enhancer acts in the N-myc context and is not under the control of negative regulatory elements located in the first intron. Moreover, the R4 element (somite enhancer) does not contribute to branchial arch expression as proposed in our initial report.

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