ACKNOWLEDGMENTS
We thank B. Cullen, A. Goldstrohm, P. Grabowski, J. Keene, and C. Smith for critically reading the manuscript and for insightful suggestions. We thank members of the Garcia-Blanco laboratory, most especially R. Carstens, for helpful discussions.
This work was supported by a grant from the American Cancer Society. E.J.W. acknowledges the support of a predoctoral fellowship from the D.O.D. M.A.G.-B. acknowledges the support of the Raymond and Beverly Sackler Foundation.